Development Pipeline
We are engineering a broad pipeline based on clinically validated drug targets that are designed to create a high therapeutic index by maximizing potency while minimizing toxicity.
In 16 patients, JANX007 displayed: 100% achieved best PSA50 declines, with 63% achieving best PSA90 and 31% achieving best PSA99 declines. These responses were durable, with 75% and 50% of patients maintaining PSA50 and 90 declines, respectively, for at least 12 weeks. Deep and durable PSA responses were observed irrespective of resistance driver aberration status, or prior treatments with a taxane or ARPi. In RECIST-evaluable patients, anti-tumor activity was observed with confirmed and unconfirmed partial responses in 50% (4/8) of patients.
Updated results as of April 2025 showed a median radiographic progression-free survival (rPFS) of 7.5 months across the same group of 16 patients, and 7.9 months in those treated at higher doses. Six-month rPFS rates were 65% overall and 78% in the higher-dose group. JANX007 has displayed a well-tolerated safety profile, with most adverse events being mild (Grade 1–2) and primarily occurring in Cycle 1.